Transcranial application of manganese chloride enables neuronal tract tracing using MEMRI
Tatjana Atanasijevic 1 , Theodore L. Roth 2 , Dorian B. McGavern 2 , and Alan P. Koretsky 1
LFMI, NINDS, NIH, Bethesda, MD, United
NIH, Bethesda, MD, United States
There has been increased interest in neuronal tract
tracing using Manganese Enhanced Magnetic Resonance
Imaging (MEMRI). Typically manganese chloride is
administered to an animal by direct injection into the
brain. Here it is demonstrated that manganese chloride
solution can diffuse through the rat scull bone when
applied directly on the exposed scull. Signal
enhancement has been observed in the expected neuronal
pathway. This offers the possibility of much less
invasive manganese delivery method for MEMRI.
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