Tetra-manganese Polyoxometalates: a new candidate contrast agent for MRI
Xiaoyong Zhang 1 , Jie Song 1 , Sha Wang 1 , Brenda Robledo 1 , Craig L Hill 2 , Shuming Nie 1 , and Xiaoping Hu 1
Department of Biomedical Engineering, Emory
University, Atlanta, Georgia, United States,
of Chemistry, Emory University, Atlanta, Georgia, United
The purpose of this work was to synthesize a new
tetramanganese cluster in a POM chelate frame named
tetra-manganese Polyoxometalates (Mn4POM) and to
evaluate its application as a contrast agent for MRI.
X-ray single crystal diffraction showed Mn4POM has the
tetra-manganese (Mn4) core within its crystal structure.
When cells were exposed to low concentrations of Mn4POM,
no cytotoxicity was caused. MRI demonstrated that cells
incubated with Mn4POM showed significant increase in R1,
compared with cells incubated with MnCl2. Our results
indicate Mn4POM is a new candidate contrast agent with
better MR contrast than free Mn2+, likely due to the Mn4
core within its crystal structure, suggesting that
Mn4POM may also be used for in vivo contrast
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