Deuterium prolonged relaxation reveals the macromolecular content in MRI

Recently, the deuterium oxide(D ₂ O) has been used as a negative contrast agent for perfusion imaging by indirectly monitoring the infused deuterium via the conventional protonium imaging. It is also noticed that the H/D isotope exchange effect of deuterium can prolong the T ₁ and T ₂ relaxation of protonium. In this study, we aimed to investigate the contrast mechanism in an environment with macromolecules. The r ₁ relaxivity of D ₂ O is nearly irrelevant to BSA concentration, while the r ₂ has a linear correlation with BSA concentration. It is found that the contrast mechanism is sensitive to the macromolecular content.

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