Abstract #2838
Quantitative 19 F MRI and CT Tracking of Microencapsulated Stem Cells in a Rabbit Peripheral Arterial Disease Model
Guan Wang 1,2 , Yingli Fu 1 , Shashank Sathyanarayana Hegde 1 , Steven M. Shea 3 , and Dara L. Kraitchman 1,4
1
Russell H. Morgan Dept. of Radiology &
Radiological Sciences, Johns Hopkins University,
Baltimore, MD, United States,
2
Electrical
& Computer Engineering, Johns Hopkins University,
Baltimore, MD, United States,
3
Corporate
Technology, Siemens Corporation, Baltimore, MD, United
States,
4
Molecular
and Comparative Pathobiology, Johns Hopkins University,
Baltimore, MD, United States
Nearly 12% of Americans suffer from peripheral arterial
disease (PAD) with stem cell therapies providing a new
alternative treatment for the most severe cases.
Microencapsulated stem cells (SCs) offer a novel means
to transplant mismatched cells to avoid immunorejection
and enable tracking using conventional imaging
modalities. Using a rabbit model of PAD, we determine
the ability of c-arm CT and MRI to serially measure
capsule persistence and concentration in an
immunocompetent rabbit after xenogenic (Xeno) or
allogenic (Allo) SC microcapsule delivery. XenoSCs were
as well tolerated as AlloSCs and could be accurately and
reproducibly tracked by CT and MRI.
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