Abstract #2839
Correlation of glucose metabolism and apparent diffusion coefficient of malignant disease evaluated with simultaneous hybrid PET/MRI
Jianhua Yan 1 , Jason Chu-Shern Lim 1 , Hoi Yin Loi 2 , Ivan WK Tham 1,3 , John James Totman 1 , Arvind Kumar Sinha 2 , Swee Tian Quek 2 , and David W Townsend 1,2
1
A*STAR-NUS, Clinical Imaging Research
Center, Singapore, Singapore, Singapore,
2
Department
of Diagnostic Radiology, National University Hospital,
Singapore, Singapore,
3
National University
Cancer Institute, Singapore, Singapore
Positron emission tomography (PET) with
[18F]flurodeoxyglucose (FDG) provides quantitative
information regarding cellular glucose metabolism. The
standardized uptake value (SUV) is commonly used to
evaluate tumor glucose metabolism, which is biomarker
for clinical diagnosis of tumor malignancy, disease
recurrence, and metabolic response to therapy.
Diffusion-weighted MRI (DWI) is also increasingly used
in the evaluation of malignant disease. By combining two
or more images of the same area with different diffusion
weighting, water movement can be quantified as the
apparent diffusion coefficient (ADC) . Like the SUV from
PET/CT, ADC has been used clinically to differentiate
benign from malignant tumors and to assess tumor grade,
delineate tumor extent and predict survival3. Results of
several studies have suggested an inverse correlation
between SUV and ADC across varying malignancies
including the first study evaluated on a simultaneous
PET/MRI hybrid imaging system4, which has the capability
of eliminating registration error due to separate PET/CT
and MRI examinations and minimizing potential
physiological and treatment changes due to the time
interval between the PET and MRI examinations. The
purpose of this study is to continue to investigate
whether FDG-PET and ADC have significant correlation
evaluated on simultaneous PET/MRI.
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