Abstract #2844
nanoPARCEL probe : soft nanoparticles containing MRI and fluorescence imaging probes
Shuhei Murayama 1,2 , Jun-ichiro Jo 1 , Yuka Shibata 2 , Kun Liang 3 , Tomofumi Santa 2 , Tsuneo Saga 1 , Ichio Aoki 1 , and Masaru Kato 2
1
Molecular Imaging Center, National Institute
of Radiological Sciences, Chiba, Chiba, Japan,
2
Graduate
School of Pharmaceutical Sciences and GPLLI Program, The
University of Tokyo, Tokyo, Tokyo, Japan,
3
Center
for Medical Systems Innovation Summer Internship
Program, The University of Tokyo, Tokyo, Tokyo, Japan
We developed a simple method to prepare PEG-based soft
nanoparticles that encapsulate dual imaging probes. The
nanoparticles were administrated to mice and the
pharmacokinetics of the nanoparticles was analyzed by
means of MRI, fluorescence spectroscopy, and
transmission electron microscopy. The soft nanoparticles
were excreted by the mice rapidly through the urine
without collapse and without leaking of the probe. The
pharmacokinetics of the nanoparticles was not changed by
the encapsulated molecules and acute toxicity to mice
was negligible. It was expect that these PEG-based soft
nanoparticles will be applicable for use as a safe
diagnostic agent.
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