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Abstract #2845

Clustering and rationing of Gd-enhanced voxels by injection of Gd-labelled RBC, a tool to quantify functional information from MR images

Enza Di Gregorio 1 , Giuseppe Ferrauto 1 , Stefania Lanzardo 1 , Eliana Gianolio 1 , and Silvio Aime 1

1 Molecular Biotechnologies & Health Sciences, University of Torino, Torino, Italy

Different MRI contrast agents have been developed as blood pool agents and are currently used in clinical and/or pre-clinical applications. One of the issues related to their use deals with their possible extravasations. Herein, we suggest a new way to get rid of this problem by using Gd-labelled RBCs that remain fully confined in the blood vasculature. Since tumor vasculature is one of the most intensively investigated aspects of the tumor growth the evaluation of vascular volume inside tumor region is of huge interest for the tumor staging and for the evaluation of anti cancer treatments.

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