Abstract #2846
Derivable High Spin Fe(III) and Mn(II) Phosphonate Scaffolds for Molecular MRI
Chris Lascola 1 , Talaignair Venkatraman 2 , Karel Base 3 , and Haichen Wang 4
1
Radiology, Duke University Medical Center,
Durham, NC, United States,
2
Duke
University Medical Center, NC, United States,
3
Radiology,
Duke University Medical Center, NC, United States,
4
Neurology,
Duke University Medical Center, NC, United States
Gd(III) complexes have proven invaluable for blood pool
and interstitial contrast, however their use as targeted
intracellular paramagnetic reporters has been less
successful. Paramagnetic ligands ideally must not only
maintain low molecular weight but also possess favorable
chemical properties to enable optimal biodistribution.
To meet this challenge, we have investigated a new class
of low molecular weight, high spin Fe(III) and Mn(II)
chelate complexes based on pyrophosphate and
bisphosphonate ligands, respectively, that demonstrate
excellent chemical stability, strong relaxivity, and
broad potential for derivatization and paramagnetic
labeling.
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