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Abstract #2852

Gd-Complexes of DO3A-benzothiazole Conjugate for MRI Theragnostic Agents

Ki-Hye Jung 1 , Hee-Kyung Kim 2 , Min-Kyoung Kang 2 , Soyeon Kim 2 , Hyun-Jeong Jeong 2 , Garam Choi 2 , Ji-Ae Park 3 , Eun-Young Jeon 4 , Tae-Jeong Kim 1 , and Yongmin Chang* 2,5

1 Department of Applied Chemistry, Kyungpook National University, Daegu, Korea, 2 Department of Medical & Biological Engineering, Kyungpook National University, Daegu, Korea, 3 Molecular Imaging Research Center, Korea Institute of Radiological & Medical Science, Seoul, Korea, 4 Institute of Biomedical Engineering, Kyungpook National University, Daegu, Korea, 5 Department of Diagnostic Radiology and Molecular Medicine, Kyungpook National University, Daegu, Korea

We report the synthesis of 1,4,7,10-tetraazacyclododecane-1,4,7-trisacetic acid (DO3A) derivatives of benzothiazole and their Gd(III) complexes of the type [Gd(DO3A-BTA)(H 2 O)] ( 2a , b ) for use as a single molecule theranostic agent. The complexes are not only tumor-specific but also intracellular, enhancing MR images of cytosols and nuclei of tumor cells such as MCF-7, MDA-MB-231, SK-HEP-1, HeLa, and Caki-2. 2a and 2b reveal antiproliferative, activities as demonstrated by GI 50 and TGI values obtainable form the cell counting kit-8 (CCK-8) assays performed on these cell lines.

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