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Abstract #2853

Hexameric Mn(II)-EDTA Complex as Contrast agent for High Field MR Imaging

Jiang Zhu 1,2 , Eirc Gale 1 , Iliyana Atanasova 3 , and Peter Caravan 1

1 Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2 Sichuan Key laboratory of Medical Imaging, Nanchong, Sichuan, China, 3 Massachusetts Institute of Technology, Cambridge, MA, United States

Here we describe the synthesis and characterization of a hexameric Mn(II)-based MR contrast agent. The hydration state and other kinetic and thermodynamic parameters were determined by 17O NMR method. The small, compact size of this hexamer exhibits greater relaxivity at low, intermediate and high fields compared to its monomeric analog.The intermediate lower case Greek tau R and relatively rapid water exchange rate make this Mn-EDTA multimer a good candiate for high-field MRI contrast agent applications.

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