Abstract #2854
MRI of Cardiac Function and Apoptosis in Fas Ligand Mouse Model of Dilated Cardiomyopathy and Heart Failure
Patrick Winter 1 , Xiaoyang Qi 2 , Zhengtao Chu 2 , Enkhsaikhan Purevjav 3 , and Jeffrey Towbin 3
1
Radiology, Cincinnati Children's Hospital,
Cincinnati, OH, United States,
2
Hematology
and Oncology, University of Cincinnati, Cincinnati, OH,
United States,
3
Heart
Institute, Cincinnati Childrens Hospital, Cincinnati,
OH, United States
The Fas ligand (FasL) is a signaling protein that causes
programmed cell death, also called apoptosis. An MRI
contrast agent targeted to apoptosis can be formulated
by incorporating paramagnetic chelates onto SapC-DOPS
vesicles. Mice that overexpress FasL in the heart were
imaged at 7T with standard cardiac MRI and molecular
imaging of apoptosis. Cardiac MRI revealed that the
transgenic mice had impaired ejection fraction and left
ventricular hypertrophy. Injection of Gd-SapC-DOPS
vesicles produced higher signal enhancement in FasL mice
compared to the control animals, suggesting myocardial
apoptosis in this animal model.
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