Abstract #2855

Non-invasive imaging of deep venous thrombi by 19F MRI using targeted perfluorcarbon nanoemulsions

Sebastian Temme ¹ , Christoph Grapentin ² , Christine Quast ¹ , Christoph Jacoby ¹ , Zhaoping Ding ³ , Friederike Mayenfels ⁴ , Jrgen Schrader ¹ , and Ulrich Flgel ¹

¹ Molecular Cardiology, University of Dsseldorf, Dsseldorf, NRW, Germany, ² Pharmaceutical Technology and Biopharmacy, University of Freiburg, Freiburg, BW, Germany, ³ Molecular Cardiology, University of Dsseldorf, Dsseldorf, Germany, ⁴ University of Freiburg, Freiburg, BW, Germany

Detection of deep venous thrombi which are not accessible by ultrasound is still a serious challenge. Therefore a non-invasive technique for unequivocal identification of those thrombi for diagnosis and subsequent monitoring of antithrombotic therapy would be highly desirable. Therefore we applied a novel sterol-based post-insertions technique to generate stable lower case Greek alpha

2-antiplasmin targeted PFC-NE for the rapid, highly specific and unequivocal identification of freshly developed deep venous thrombi, which might have a potential clinical application in detection of rethrombosis or lung thromboembolism. Moreover, we propose that the sterol-based post-insertion technique is a promising platform to equip PFC-NE with different ligands (peptides, antibodies etc.) for in-vivo 19F MRI of specific targets.

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