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Abstract #2856

Anti-fouling Poly Ethylene Glycol Based Copolymer Coated Iron Oxide Nanoparticle Probes for Reducing Non-specific Uptake and Improving Cell Targeting

Yuancheng Li 1,2 , Run Lin 1,2 , Liya Wang 1,2 , Jing Huang 1,2 , Lily Yang 3 , and Hui Mao 1,2

1 Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, United States, 2 Center for Systems Imaging, Emory University, Atlanta, GA, United States, 3 Department of Surgery, Emory University, Atlanta, GA, United States

One of the major challenges in applications of IONPs for in vivo imaging is the non-specific uptake of the nanoparticles by the macrophages and reticuloendothelial system (RES). Non-specific uptake may lead to lower blood circulation time and introduce interfering background signal, thus substantial reduction in the efficiency of target-directed imaging. In this work, iron oxide nanoparticle molecular imaging probes were modified with a novel anti-fouling poly ethylene glycol based copolymer coating to reduce the non-specific absorption of macromolecules and non-specific uptake by macrophages, thus improve cell targeting.

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