Abstract #2856
Anti-fouling Poly Ethylene Glycol Based Copolymer Coated Iron Oxide Nanoparticle Probes for Reducing Non-specific Uptake and Improving Cell Targeting
Yuancheng Li 1,2 , Run Lin 1,2 , Liya Wang 1,2 , Jing Huang 1,2 , Lily Yang 3 , and Hui Mao 1,2
1
Department of Radiology and Imaging
Sciences, Emory University, Atlanta, GA, United States,
2
Center
for Systems Imaging, Emory University, Atlanta, GA,
United States,
3
Department of Surgery, Emory
University, Atlanta, GA, United States
One of the major challenges in applications of IONPs for
in vivo imaging is the non-specific uptake of the
nanoparticles by the macrophages and reticuloendothelial
system (RES). Non-specific uptake may lead to lower
blood circulation time and introduce interfering
background signal, thus substantial reduction in the
efficiency of target-directed imaging. In this work,
iron oxide nanoparticle molecular imaging probes were
modified with a novel anti-fouling poly ethylene glycol
based copolymer coating to reduce the non-specific
absorption of macromolecules and non-specific uptake by
macrophages, thus improve cell targeting.
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