Abstract #2857
Simultaneous 19F/1H MR Molecular Imaging of Neovascularization in Pulmonary Inflammation
Anne Schmieder 1 , Huiying Zhang 1 , Jochen Keupp 2 , Shelton Caruthers 2 , Samuel Wickline 1 , Elizabeth Wagner 3 , and Gregory Lanza 1
1
Washington University Medical School, St.
Louis, MO, United States,
2
Philips
Research Laboratories, Hamburg, Germany,
3
Johns
Hopkins University, Maryland, United States
Angiogenesis is an important constituent of many
inflammatory pulmonary diseases, which is poorly
understood. Early neovascular expansion in the lungs in
preclinical models and patients is very difficult to
assess noninvasively, particularly quantitatively. The
present study demonstrated that (19)F/(1)H MR molecular
imaging with αvβ3-targeted perfluorocarbon nanoparticles
can be used to directly measure neovascularity in a rat
asthma model. In rats 7, 14, and 21 days after house
dust mite induction of asthma, simultaneous (19)F/(1)H
MR imaging at 3T revealed a marked (19)F signal in
animals 2 h following αvβ3-targeted perfluorocarbon
nanoparticles that was significantly greater than the
signal found in the saline treated controls. Our results
demonstrate that (19)F/(1)H MR molecular imaging with
αvβ3-targeted perfluorocarbon nanoparticles provides a
means to assess the extent of systemic
neovascularization in the lung. This novel application
of dual 1H/19F MR molecular imaging is a clinically
translatable approach for noninvasive temporal-spatial
assessment of lung angiogenesis, which may provide a
better understanding about the role of pulmonary
angiogenesis in asthma.
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