Abstract #2862
Glucan Particles as a new platform for MRI visualization of inflammatory process
Francesca Garello 1 , Cristina Chirizzi 1 , Francesca Arena 2 , Sara Figueiredo 3 , Daniela Delli Castelli 1 , Valeria Menchise 1 , Silvio Aime 1,2 , and Enzo Terreno 1,2
1
Molecular biotechnology and health sciences,
University of Torino, Torino, Torino, Italy,
2
Center
for Preclinical Imaging, University of Torino,
Colleretto Giacosa, Torino, Italy,
3
Department
of Life Sciences, Faculty of Sciences and Technology,
and Center for Neurosciences and Ce, University of
Coimbra, Coimbra, Coimbra, Portugal
Glucan particles (GPs) could be considered innovative
and biocompatible microcarriers. Their high affinity for
Dectin-1 receptor, expressed on different phenotypes of
immune system cells, makes them suitable for imaging
inflammatory processes. In this work, GPs were
efficiently loaded with either paramagnetic Gd-based
compounds (for proton MRI) or perfluorocarbons (PFCs,
for
19
F
MRI). The carriers obtained showed very high values of
relaxivity and fair fluorine payloads. The limit of
sensitivity related to loaded GPs was explored both by
1
H
and
19
F
MRI. Moreover, J774.A1 macrophage incubation with loaded
GPs and subsequent MRI of cells at 7 T were performed.
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