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Abstract #2866

Magnetic Nanoparticles extracted from magnetotactic bacteria as contrast agents for MRI

Pasquina Marzola 1 , Leonardo Ghin 2 , Stefano Tambalo 3 , Giamaica Conti 3 , Silvia Mannucci 3 , Alice Busato 3 , Elvira Fantechi 4 , Claudia Innocenti 4 , Claudio Sangregorio 4 , Alessandro Lascialfari 5 , Tomas Orlando 5 , Roberto Bassi 2 , and Andrea Sbarbati 3

1 Department of Computer Science, University of Verona, Verona, Italy, 2 Department of Biotechnology, University of Verona, Verona, Italy, 3 Department of Neurological and Movement Science, University of Verona, Verona, Italy, 4 INSTM-LaMM, Dept. of Chemistry, University of Florence, Florence, Italy, 5 Department of Physics, University of Milan, Milan, Italy

Naturally occurring iron-oxide nanoparticles, namely Magnetosomes (MS), are here proposed as theranostic agents for imaging and thermotherapy of tumors. Magnetosomes, produced by magnetotactic bacteria, are organized in chains that are used by bacteria as a compass for geomagnetic navigation. In this paper , several techniques have been used to characterize magnetic nanoparticles and we demonstrate that MS extracted from Magnetospirillum gryphiswaldence strain MSR-1 have high transversal relaxivity and high hyperthermal efficiency.

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