Abstract #2865
Copper Ions Responsive Bimodal (optical/MRI) Contrast Agent for Cellular Imaging
Sankarprasad Bhuniya 1 , Jongeun Kang 1,2 , and Kwan Soo Hong 3,4
1
Division of Magnetic Resonance Research,
Korea Basic Science Institute, Ochang Eup, Chungbook,
Korea,
2
Graduate
School of Analytical Science and Technology, Chungnam
National University, Daejeon, Korea,
3
Division
of Magnetic Resonance Research, Korea Basic Science
Institute, Ochang -Eup, Chungbook, Korea,
4
bGraduate
School of Analytical Science and Technology, Chungnam
National University, Daejeon, Korea
We have synthesized a Cu2+ triggered bimodal MRI
contrast agent (1) comprising 1,8-naphthalimide as a
fluorescence reporter and a diethylenetriamine
tetraacetic acid (DTTA) unit as a chelator for Gd3+
ions. In the presence of Cu2+ ions, the fluorescence
intensity of 1 decreased because of the paramagnetic
nature of Cu2+ ions. In contrast, with the addition of
Cu2+ ions, first, the total number of water molecules
coordinated to 1 increased, and then the T1-weighted MR
signal increased. The new bimodal contrast agent was
nontoxic and able to provide bimodal, i.e., fluorescence
and T1-weighted MRI imagings in the cellular medium in
the presence of Cu2+ ions. This new contrast agent can
be used to detect free Cu2+ ions in living cells and
inspire researchers to develop new probes to detect free
metal ions in vivo.
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