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Abstract #2868

Influence of phospholipid enriched 19 F nanoparticles on fluorine uptake in dendritic cells

Stefano Lepore 1 , Karl Sydow 2 , Susanne Drechsler 1 , Min-Chi Ku 1 , Helmar Waiczies 1,3 , Conrad Martin 1 , Irene Schuetz 2 , Bettina Purfrst 4 , Margitta Dathe 2 , Thoralf Niendorf 1,5 , and Sonia Waiczies 1,5

1 Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrck Center for Molecular Medicine, Berlin, Berlin, Germany, 2 Department of Medicinal Chemistry/Chemical Biology, Leibniz-Institut fr Molekulare Pharmakologie, Berlin, Berlin, Germany, 3 MRI.Tools GmbH, Berlin, Berlin, Germany, 4 Electron Microscopy, Max Delbrck Center for Molecular Medicine, Berlin, Germany, Berlin, Berlin, Germany, 5 Experimental and Clinical Research Center (ECRC), Berlin, Berlin, Germany

Studying the migratory behavior of immune cells is pivotal to better understand the development of immune-mediated pathologies, It has been already demonstrated that fluorine ( 19 F) MRI enables spatio-temporal tracking of dendritic cells (DC) in vivo . The aim of this study is to overcome the 19 F sensitivity barriers by increasing the uptake of 19 F nanoparticles in DC. Therefore we explored the impact of aminophospholipids incorporated into the 19 F nanoparticle on uptake by DC and on labeling. We show how this incorporation resulted in fluorine uptake increase confirmed by 19 F spectroscopy and microscopy, with minor changes in the migration capability of DC.

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