Abstract #2869
Developing Pan-cancer targeting MRI contrast agents that self-assemble in malignant tumors
Joshua E Goldberger 1 , Arijit Ghosh 2 , Christian Buettner 2 , Michelle Williams 3 , and Michael F. Tweedle 3,4
1
Chemistry and Biochemistry, The Ohio State
University, Columbus, OH, United States,
2
Chemistry,
The Ohio State University, Columbus, OH, United States,
3
Wright
Center of Innovation in Biomedical Imaging, The Ohio
State University, Columbus, OH, United States,
4
Radiology,
Chemistry and Biochemistry, Biophysics, The Ohio State
University, Columbus, OH, United States
FDG PET targets Warburg metabolism (including low pHe)
but suffers low spatial resolution-based sensitivity (~1
cm). We developed a strategy for controlling the
self-assembly transitions of Gd-PA molecules in the 10
1000+ nm range as a function of pHe and concentration,
measured the transitions in serum, and biodistributions
in mice, uncovering significant differences in behavior
among transitioning examples. If we can harness the
power of self-assembly to trap Gd chelates in the acidic
tumor environment, we should be able to image tumors at
the < 1 mm spatial resolution of MRI using Warburg
metabolism as the target.
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