Shrinking microfabricated multispectral MRI contrast agents to the nanoscale

Newly developed microfabricated multispectral MRI agents offer multispectral contrast that is tunable over broad frequency ranges allowing for the possibility of highly multiplexed imaging. However, such agents has thus far been limited by their relatively large sizes. To overcome this limitation and expand their biological utility, this work shows how it is possible to shrink these agents to sub-micron and nano size scales. The nanofabrication techniques involved, and the NMR spectral signatures that result from agents over a 100 times less massive than any previously published equivalent are presented, and future benefits and limits to further agent miniaturization are discussed.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.