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Abstract #2870

Shrinking microfabricated multispectral MRI contrast agents to the nanoscale

Gary Zabow 1,2 , Stephen Dodd 1 , John Moreland 2 , and Alan Koretsky 1

1 NINDS, NIH, Bethesda, Maryland, United States, 2 Physical Measurements Division, NIST, Boulder, Colorado, United States

Newly developed microfabricated multispectral MRI agents offer multispectral contrast that is tunable over broad frequency ranges allowing for the possibility of highly multiplexed imaging. However, such agents has thus far been limited by their relatively large sizes. To overcome this limitation and expand their biological utility, this work shows how it is possible to shrink these agents to sub-micron and nano size scales. The nanofabrication techniques involved, and the NMR spectral signatures that result from agents over a 100 times less massive than any previously published equivalent are presented, and future benefits and limits to further agent miniaturization are discussed.

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