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Abstract #2877

Partial volume correction of 1 H brain CSI by grid shifting (PANGS)

Yi Zhang 1,2 , Jinyuan Zhou 1,3 , and Paul Bottomley 1,2

1 Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, 2 Department of ECE, Johns Hopkins University, Baltimore, MD, United States, 3 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

The low spatial resolution typical of chemical shifting imaging (CSI) studies causes partial volume errors and signal bleed, especially in voxels near the scalp. The standard solution is to apply spatial apodization filters, which adversely affect spatial resolution. Here, a novel automated strategy for partial volume correction employing grid shifting (PANGS), is presented that minimizes partial volume bleed without compromising spatial resolution. PANGS is applied to significantly reduce lipid artifacts in 1H brain CSI and metabolite maps, and to improve metabolite detection in cortical regions.

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