Spectral Alignment Improves GABA Measures in Schizotypal Personality Disorder
Sai Krishna Merugumala 1 , Huijun Liao 1 , Nick Bolo 2 , Elisabetta Del Re 3 , Robert William McCarley 3 , and Alexander Paul Lin 1
Radiology, Brigham and Women's Hospital,
Boston, MA, United States,
Beth Israel Deaconess Medical Center, Boston, MA, United
Veterans Affairs Boston Healthcare System, Brockton, MA,
Abnormalities in the GABA levels in the brain are
associated with the symptoms of Schizophrenia and
Schizotypal Personality Disorder. Estimating GABA with
MRS using MEGA-PRESS in brain ROIs like the auditory
cortex is complicated by inherent problems with the
spectral edited MRS and issues such has gray matter
volume loss in the subjects. A method for improving the
resulting MEGA-PRESS difference spectrum is spectral
alignment where frequency and phased are optimized.
After spectral alignment, the variation between subject
scans is reduced and correlation with electrophysiology
improved with the additional processing step.
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