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Abstract #2878

Spectral Alignment Improves GABA Measures in Schizotypal Personality Disorder

Sai Krishna Merugumala 1 , Huijun Liao 1 , Nick Bolo 2 , Elisabetta Del Re 3 , Robert William McCarley 3 , and Alexander Paul Lin 1

1 Radiology, Brigham and Women's Hospital, Boston, MA, United States, 2 Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, United States, 3 Psychiatry, Veterans Affairs Boston Healthcare System, Brockton, MA, United States

Abnormalities in the GABA levels in the brain are associated with the symptoms of Schizophrenia and Schizotypal Personality Disorder. Estimating GABA with MRS using MEGA-PRESS in brain ROIs like the auditory cortex is complicated by inherent problems with the spectral edited MRS and issues such has gray matter volume loss in the subjects. A method for improving the resulting MEGA-PRESS difference spectrum is spectral alignment where frequency and phased are optimized. After spectral alignment, the variation between subject scans is reduced and correlation with electrophysiology improved with the additional processing step.

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