Meeting Banner
Abstract #2880

Investigating the reproducibility on the quantification of ^-aminobutyric acid (GABA) in visual cortex

Tzai-You Wu 1 , Chun-Hao Fang 1 , Yi-Ru Lin 1 , and Shang-Yueh Tsai 2

1 Electronic and Computer Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan, 2 Graduate Institute of Applied Physics, National Chengchi University, Taipei, Taiwan

Quantification of ^-Aminobutyric acid (GABA) assessed by MEGA-PRESS sequence need to be carefully investigated because of its low concentration and can be sensitive to editing efficiency. In this study the inter- and intra-subject reproducibility of GABA quantified using three quantification methods including integration, fitting using two Gaussian shape and LCModel is investigated. GABA spectra were collected from sixteen healthy subjects in visual cortex. Results showed that three quantification methods exhibit similar intra-subject CV ranging from 11.1% to 15.3%. GABA+ quantified by direct integration is relatively stable among three quantification methods, which implies simple quantification strategy is sufficient for GABA spectra.

This abstract and the presentation materials are available to members only; a login is required.

Join Here