Impact of spectra quality on GABA quantitation with 1 H-MEGA-PRESS sequence

In the present study in vitro measurements were performed to evaluate the accuracy and reproducibility of GABA detection with ¹ H-MEGA-PRESS. Spectra were acquired in a phantom containing several metabolites of defined concentrations emulating their composition in the brain. The obtained spectra were used to simulate in vivo conditions by reducing SNR _GABA and broadening linewidths. It was figured out that for sufficiently small CVs (< 7 %) a SNR _GABA of at least 2 is required, whereas for SNR _GABA > 6 the CVs remain independent of FWHM. These results were compared to an in vivo investigation in one healthy volunteer.

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