Abstract #2889
Improvements on extraction of glutamate and glutamine from GABA editing spectra at 3 Tesla
Jan Willem van der Veen 1 , Stefano Marenco 2 , and Jun Shen 1
1
Magnetic Resonance Spectroscopy Core, NIH,
NIMH, Bethesda, Maryland, United States,
2
NIH,
NIMH, Maryland, United States
Due to the time constraint of many clinical studies, it
is highly desirable to acquire glutamate, glutamine and
GABA in a single scan. In this study 141 GABA editing
scans were fitted with a basis set of nine metabolite
signals simulated by GAMMA with a novel fitting
procedure to extract concentrations of glutamate,
glutamine, and GABA, taking advantage of the partial
spectral separation of glutamate and glutamine by the
GABA editing pulse. The high SNR afforded by averaging
the large number of spectra also allowed in vivo
validation of metabolite chemical shifts and J coupling
constants.
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