Comparison of the Repeatability of GABA-Edited Magnetic Resonance Spectroscopy with and without Macromolecule Suppression

In vivo quantification of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) is possible with J-difference edited proton magnetic resonance spectroscopy (MRS), but concentration measurements suffer from macromolecule (MM) contamination. This is a result of a co-edited MM resonance being partially excited during acquisition. Using symmetric editing-based suppression, however, the MM signal can be suppressed. Here, the repeatability of GABA-edited MRS with and without MM suppression is evaluated and compared. It is shown that MM suppression is comparable in repeatability to standard GABA-editing. MM-suppressed GABA measurement offers increased measurement specificity and potentially an increased ability to discriminate between participants.

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