Abstract #2907
Feasibility and reproducibility of neurochemical profile quantification in the human hippocampus at 3T
Petr Bednarik 1,2 , Amir Moheet 1 , Dinesh K Deelchand 1 , Uzay E Emir 3 , Elizabeth R Seaquist 1 , and Gulin Oz 1
1
University of Minnesota, Minneapolis, MN,
United States,
2
Central
Europeran Institute of Technology, Masaryk University,
Brno, Czech Republic,
3
FMRIB
Centre, Nuffield Department of Clinical Neurosciences,
University of Oxford, Oxford, United Kingdom
Hippocampus dysfunction may be involved in multiple
neurologic and neuropsychiatric diseases. We
investigated the feasibility of obtaining high quality
hippocampal spectra and the test-retest reproducibility
of hippocampal neurochemical profiles using standard 3T
hardware with an in-house implemented single-voxel,
short-echo semi-LASER sequence. Neurochemical profiles
were highly reproducible between subjects (N=6) and
between sessions (each subject scanned twice). Six
metabolites were quantified with mean CRLB ≤ 10% and
another 4 with CRLB ≤ 30%. Mean intersession CV was <10%
for 8 metabolites. This methodology will allow novel
investigations of hippocampal neurochemistry in many
common clinical conditions with widely available
hardware.
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