Constrained Source Space Spectroscopy: Multivoxel Spectroscopy Without a Gradient Readout

A novel technique was developed that can measure the spectra of discrete voxels simultaneously, without the need for a gradient readout. The technique utilizes a modified PRESS sequence to excite multiple voxels, measures their spectra simultaneously using multichannel receiver coils, and reconstructs the individual voxel spectra using SENSE. Good agreement was demonstrated in vivo using both qualitative and quantitative measurements of the techniques efficacy when compared to single voxel spectroscopy, in healthy adults and in a patient with low-grade glioma.

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