Single-shot Lactate Editing using Foci-Laser and a Multiple Quantum Filter

Lactate is an important potential cancer biomarker but measurement is hampered by intense signals of overlapping lipids, especially in the presence of motion. Here a single-shot lactate sequence has been conceived, implemented and evaluated on a Philips 3T scanner. Based on the adiabatic semi-laser single-voxel sequence, it uses FOCI RF-and-gradient pulses with large bandwidth to overcome the chemical shift displacement effect. In phantoms this flaser sequence more than doubled the lactate signal of standard PRESS. MQF-flaser included at TE/2 a 90 ^o -180 ^o -90 ^o multiple-quantum filter segment with -1:2 gradients. Lactate signals were 40% of flaser alone, while 1.3ppm lipid was totally eliminated.

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