Feasibility of high throughput high performance 1 H MRS in baby-mice
Ivan Tkac 1 , Diana Wallin 2 , Michael K Georgieff 2 , and Raghu Rao 2
Center for Magnetic Resonance Research,
University of Minnesota, Minneapolis, MN, United States,
of Pediatrics, University of Minnesota, Minneapolis, MN,
The neurochemical profile of the mouse brain is changing
extremely fast during the developmental period.
Therefore, mice have to be scan at exactly the same age
to avoid a bias caused by age dependent neurochemical
changes. This study demonstrates that by optimizing the
scanning protocol, high throughput
MRS is feasible without compromising the data quality.
The performance of this approach is demonstrated by
using the anemia mouse model. An optimized scanning
protocol enabled to scan 12 mice in a single study
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