Abstract #2913
Localised in vivo measurement of GABA and glutamate in the rat brain at 4.7T
Stephen John Sawiak 1,2 , Bianca Jupp 3 , Daniele Caprioli 3 , T Adrian Carpenter 1 , and Jeffrey W Dalley 3
1
Wolfson Brain Imaging Centre, University of
Cambridge, Cambridge, England, United Kingdom,
2
Behavioural
and Clinical Neuroscience Institute, University of
Cambridge, Cambridge, England, United Kingdom,
3
Department
of Psychology, University of Cambridge, England, United
Kingdom
The inhibitory neurotransmitter GABA plays a role in
many psychiatric and neurological conditions. It is
difficult to measure with in vivo 1H-MRS due to overlap
with more abundant metabolites. The spectral-editing
technique MEGAPRESS can be used to isolate the GABA
signal. We demonstrate for the first time that this
technique can be used in rats, and we give mean and
variability values of the concentrations obtained in the
ventral striatum.
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