Abstract #2920
The effect of spinning rate variation on lipid resonances in HR-MAS spectra of brain and muscle biopsies
Christina Stahl 1 , Gaelle Diserens 2 , Martina Vermathen 3 , Anna Oevermann 4 , Torsten Seuberlich 4 , Josiane Lauper 1 , Francesca Amati 5 , Chris Boesch 2 , and Peter Vermathen 2
1
Department of Clinical Veterinary Medicine,
Bern University, Bern, Bern, Switzerland,
2
Departments
of Clinical Research and Radiology, Bern University,
Bern, Switzerland,
3
Department of Chemistry
and Biochemistry, Bern University, Bern, Switzerland,
4
Department
of Clinical Research and Veterinary Public Health, Bern
University, Bern, Switzerland,
5
Department
of Physiology, Lausanne University, Lausanne,
Switzerland
Lipid resonances from mobile lipids can be observed by
1H NMR spectroscopy in multiple tissues and have also
been associated with malignancy. The purpose of our
study was to investigate the effect of spinning rate
variation on the HR-MAS pattern of lipid resonances in
non-neoplastic brain and muscle biopsies. We observed a
substantial increase in the relative integral of mobile
lipid resonances with high spinning rates in non-neoplastic
brain tissue biopsies, but only a mild increase in
skeletal muscle biopsies.
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