Abstract #2921
Skeletal muscle pH time course predicts water T2* during repeated exercise
Albrecht Ingo Schmid 1,2 , Kiril Schewzow 1,2 , Sigrun Goluch 1,2 , Georg Fiedler 1,2 , Fabian Niess 1,2 , Elmar Laistler 1,2 , Michael Wolzt 3 , Ewald Moser 1,2 , and Martin Meyerspeer 1,2
1
Center for Medical Physics and Biomedical
Engineering, Medical University of Vienna, Vienna,
Austria,
2
MR
Centre of Excellence, Medical University of Vienna,
Vienna, Austria,
3
Department
of Clinical Pharmacology, Medical University of Vienna,
Vienna, Vienna, Austria
During exercise, skeletal muscle T2* relaxation times
are known to change. In this study, repeated EPI and
localised 31P MRS were acquired in healthy volunteers at
7 T in one scanning session. A highly significant cross
correlation (R2 = 0.720.16) between EPI signal and
intracellular pH was found during 5 min. of plantar
flexion exercise. Apparently T2* changes during exercise
are driven by pH-dependent cellular water shift.
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