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Abstract #2926

Co-registered EPR and MRI of the mouse head indicates detailed distributions of piperidine nitroxides

Miho C Emoto 1 , Hideo Sato-Akaba 2 , Hiroshi Hirata 3 , and Hirotada G Fujii 1

1 Sapporo Medical University, Sapporo, Hokkaido, Japan, 2 Osaka University, Osaka, Japan, 3 Hokkaido University, Hokkaido, Japan

Piperidine nitroxides such as TEMPONE and TEMPOL are useful redox-sensitive probes for redox research, but due to their short lifetime in vivo, they have not been fully employed in EPR imaging studies. In this study, we developed an improved EPR imaging system with a rapid-field scanning capability, and obtained three-dimensional EPR images of piperidine nitroxides in mouse heads in 15 s. The co-registered EPR and MRI images of mouse heads clearly depict detailed distributions of TEMPONE. With this improved EPR imaging system, it is likely that piperidine nitroxides can be used to estimate redox status in in vivo systems.

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