Abstract #2927
Simultaneous 19 F MR imaging at different resonance frequencies using multi chemical shift selective RARE
Christoph Jacoby 1 , Thomas Oerther 2 , Sebastian Temme 1 , Jrgen Schrader 1 , and Ulrich Flgel 1
1
Molecular Cardiology, Heinrich Heine
University, Dsseldorf, NRW, Germany,
2
Bruker
BioSpin GmbH, Rheinstetten, Baden-Wrttemberg, Germany
In the present study a multi chemical shift selective (MCSS)
RARE sequence was used for artifact-free
19
F
MR imaging of perfluorocarbons (PFC) with complex
spectra and compared to conventional methods in terms of
sensitivity and quantifiability. Reliable quantification
was demonstrated by simultaneous imaging of various
mixtures of different PFC emulsions
ex
vivo
and
in
vivo
. The average enhancement factor was determined
to be more than two-fold as compared to single
excitation RARE without any loss of information due to
intrinsic spatial averaging mechanisms. MCSS-RARE may
also be useful for other nuclei, e.g. simultaneous
imaging of all phosphorus of ATP.
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