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Abstract #2948

Proton T 2 measurement of Lactate in Brain Tumors at 3T

Akshay Madan 1 , Sandeep Ganji 1 , Zhongxu An 1 , Elizabeth Maher 1 , and Changho Choi 1

1 UT Southwestern Medical Center, Dallas, Texas, United States

Lactate (Lac) is elevated in tumors and has been extensively studied because of its potential use in clinical diagnosis. Lac resonance at 1.31 ppm is overlapped with lipid signals which are also elevated in many tumors, thus Lac is often measured using long echo times. We aim to accomplish precise measurement of Lac T2 and absolute quantification of its concentration with corrections for the T2 relaxation effects. We measured Lac T2 in 18 glioma patients using PRESS at 8 TE's (58 - 268ms). The T2 of Lac was estimated to be 246[plusmn]20ms and was similar between tumor grades and subtype.

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