Abstract #2949
Long-term alterations of brain NAA, Cho and Cr in extremely preterm adolescents are associated with cognition
Alan Bainbridge 1 , Cheong LY Jeannie 2,3 , Peter J Anderson 3,4 , Deanne K Thompson 3 , Alan Connelly 5 , Peter J Lally 6 , Nicola J Robertson 6 , and Lex W Doyle 2,3
1
Medical Physics, UCLH NHS Foundation trust,
London, United Kingdom,
2
Royal
Women's Hospital, Melbourne, Australia,
3
Murdoch
Children's Research Institute, Melbourne, Australia,
4
University
of Melbourne, Melbourne, Australia,
5
Florey
Institute of Neurosciences and Mental Health, Melbourne,
Australia,
6
Institute
for Women's Health, University College London, London,
United Kingdom
Preterm birth is associated with increased risk of white
matter (WM) injury resulting in disrupted WM maturation
and neurodevelopmental deficits. Extremely preterm
infants(EP) are at increased risk of cerebral palsy, and
other motor and cognitive impairments. We aimed to
compare the metabolite ratios NAA/Cr, Cho/Cr and NAA/Cho
between EP and term controls at age 18 years and to
explore the association between these metabolite ratios
and full scale IQ at 18 years. This is the first study
to report long term brain metabolite differences in PC
WM in EP with Naa/Cr. Naa/Cho and Cho/Cr significantly
different compared to controls.
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