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Abstract #2949

Long-term alterations of brain NAA, Cho and Cr in extremely preterm adolescents are associated with cognition

Alan Bainbridge 1 , Cheong LY Jeannie 2,3 , Peter J Anderson 3,4 , Deanne K Thompson 3 , Alan Connelly 5 , Peter J Lally 6 , Nicola J Robertson 6 , and Lex W Doyle 2,3

1 Medical Physics, UCLH NHS Foundation trust, London, United Kingdom, 2 Royal Women's Hospital, Melbourne, Australia, 3 Murdoch Children's Research Institute, Melbourne, Australia, 4 University of Melbourne, Melbourne, Australia, 5 Florey Institute of Neurosciences and Mental Health, Melbourne, Australia, 6 Institute for Women's Health, University College London, London, United Kingdom

Preterm birth is associated with increased risk of white matter (WM) injury resulting in disrupted WM maturation and neurodevelopmental deficits. Extremely preterm infants(EP) are at increased risk of cerebral palsy, and other motor and cognitive impairments. We aimed to compare the metabolite ratios NAA/Cr, Cho/Cr and NAA/Cho between EP and term controls at age 18 years and to explore the association between these metabolite ratios and full scale IQ at 18 years. This is the first study to report long term brain metabolite differences in PC WM in EP with Naa/Cr. Naa/Cho and Cho/Cr significantly different compared to controls.

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