Abstract #2954
Whole body Radiation Induced Early Delayed Changes in Mice Brain: Behavioral Evaluation and 1H MRS Study
Mamta Aryabhushan Gupta 1 , Poonam Rana 1 , Seenu Haridas 2 , Kailash Manda 2 , BS Hemanth Kumar 1 , and Subash Khushu 1
1
NMR Research Centre, INMAS, DRDO, Delhi,
delhi, India,
2
Division
of Radiation Biosciences, INMAS, DRDO, Delhi, delhi,
India
Effect of whole body radiation exposure on central
nervous system has not been explored much in brain. In
the present study we investigate behavior evaluation and
1H MRS based early delayed cognitive and neurometabolite
changes in hippocampus at 3 months following 5Gy whole
body radiation exposure. Behavioral studies showed
locomotory and discrimination ratio impaired in
irradiated group.1H MRS revealed significant decrease in
Glutamine and significant increase in myo inositol in
irradiated group compared to controls. Our results
demonstrate whole body radiation induced cognitive
dysfunction and metabolic impairment at 3 months post
whole body irradiation.
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