Metabolite Proton T2 Relaxation Times in the Rat Brain in Vivo at 17.2 Tesla

At ultra-high magnetic fields such as 17.2 T, it is crucial to establish T ₁ and T ₂ relaxation times in order to optimize MRS acquisition parameters and to achieve proper metabolite concentration quantification. In this study we present measurements of T ₂ relaxation times of more than 18 metabolites and macromolecules in the rat brain in vivo at 17.2T. J-modulation of major brain metabolites such as glutamate and myo-inositol was adequately accounted for by our spin simulations. Compared to T ₂ values measured at lower magnetic fields, our values are shorter which is consistent with the established field-dependence of T ₂ to increased microscopic susceptibility gradients as B ₀ increases.

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