Abstract #2952
Towards metabolic profiling of the neurocircuitry of mood: small-voxel, non-water-suppressed 1 H-MRS in the nucleus accumbens, amygdala and cingulate cortex at 3T
Andreas Hock 1,2 , Niklaus Zoelch 1 , Milan Scheidegger 1,2 , Marcus Herdener 2 , Erich Seifritz 2 , and Anke Henning 1,3
1
Institute for Biomedical Engineering,
University and ETH Zurich, Zurich, Zurich, Switzerland,
2
Department
of Psychiatry, Psychotherapy and Psychosomatics Hospital
of Psychiatry, University of Zurich, Zurich, Zurich,
Switzerland,
3
Institute
for Biological Cybernetics, Max Planck Institute,
Tuebingen, Baden Wrttemberg, Germany
MRS measurements in small, specific human brain regions
with high clinical relevance for neuropsychiatric
disorders are executed using non-water suppressed MRS
enabling frequency and phase alignment of individual
FIDs prior averaging. Results obtained from 16 healthy
volunteers from the anterior cingulate cortex, the
nucleus accumbens, the amygdala, and the occipital
cortex show, that Creatine, N-acetyl-aspartate,
glutamate and the combination of Glu and glutamine,
choline and myo-inositol could be quantified reliably in
group average spectra and by far the most individual
data sets. This may promote better understanding of
possible dysfunctions of brain metabolism and
neurotransmission in neuropsychiatric disorders.
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