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Abstract #2952

Towards metabolic profiling of the neurocircuitry of mood: small-voxel, non-water-suppressed 1 H-MRS in the nucleus accumbens, amygdala and cingulate cortex at 3T

Andreas Hock 1,2 , Niklaus Zoelch 1 , Milan Scheidegger 1,2 , Marcus Herdener 2 , Erich Seifritz 2 , and Anke Henning 1,3

1 Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Zurich, Switzerland, 2 Department of Psychiatry, Psychotherapy and Psychosomatics Hospital of Psychiatry, University of Zurich, Zurich, Zurich, Switzerland, 3 Institute for Biological Cybernetics, Max Planck Institute, Tuebingen, Baden Wrttemberg, Germany

MRS measurements in small, specific human brain regions with high clinical relevance for neuropsychiatric disorders are executed using non-water suppressed MRS enabling frequency and phase alignment of individual FIDs prior averaging. Results obtained from 16 healthy volunteers from the anterior cingulate cortex, the nucleus accumbens, the amygdala, and the occipital cortex show, that Creatine, N-acetyl-aspartate, glutamate and the combination of Glu and glutamine, choline and myo-inositol could be quantified reliably in group average spectra and by far the most individual data sets. This may promote better understanding of possible dysfunctions of brain metabolism and neurotransmission in neuropsychiatric disorders.

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