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Abstract #2956

Investigating Longitudinal Metabolite Changes Associated with Epileptogenesis in vivo in a Rat Model of Interictal Spiking Using H MRS at 7 Tesla

Helen Wu 1 , Danielle Senador 2 , Matthew Galloway 3 , Jeffrey Loeb 2,4 , and Jeffrey Stanley 5

1 Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United States, 2 Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, MI, United States, 3 Psychiatry and Behavioral Neurosciences, Wayne State University, MI, United States, 4 Neurology, University of Illinois at Chicago, IL, United States, 5 Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, MI, United States

We used a chronic tetanus toxin rat model of interictal spiking as a platform to investigate longitudinal metabolite changes associated with epileptogensis. Our 1H MRS performed in vivo at 7T provides the opportunity to examine neocortical metabolite changes associated with the epileptogenic process in context of concurrent long term EEG changes. The goal of this study is to identify key biomarkers associated with epileptogensis in the neocortex, which we believe exhibits a different pattern of metabolite level changes than those observed in the hippocampus. Identification of such markers can help guide future clinical and pharmacological approaches.

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