Abstract #2961
In-vivo Longitudinal Relaxation Enhancements (LREs) of Central-Nervous-System Metabolites at 21.1 T upon Stroke
Noam Shemesh 1 , Jens T Rosenberg 2,3 , Jean-Nicolas Dumez 1 , Samuel Colles Grant 2,3 , and Lucio Frydman 1,2
1
Chemical Physics, Weizmann Institute of
Science, Rehovot, Israel,
2
National
High Magnetic Field Laboratory, The Florida State
University, Tallahassee, FL, United States,
3
Chemical
& Biomedical Engineering, The Florida State University,
Tallahassee, Florida, United States
Apparent metabolic T
1
s are important for
quantification of MRS spectra in vivo. Longitudinal
Relaxation Enhancements (LREs) upon band-selective
excitation are well-known for large, slowly tumbling
molecules. The surprising existence of LREs for small
endogenous Central Nervous System metabolites was only
recently reported ex vivo. Here, we aim at developing
and applying a localized LRE-MRS sequence capable of
detecting LREs in vivo, testing their potential as
stroke biomarkers in the rat. At 21.1 T, the Cre
resonance showed a statistically significant LRE effect
upon spectrally-selective excitation, which was
time-dependent. Lac apparent T
1
s also varied
significantly upon stroke. These findings suggest LREs
as novel potential stroke biomarkers.
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