Abstract #2962
Neurochemical changes in scopolamine induced memory impairment in the mouse are detectable by in vivo magnetic resonance spectroscopy
Dong-Cheol Woo 1,2 and Robert E. Lenkinski 2
1
Biomedical Research Center, ASAN Institute
for Life Science, Asan Medical Center, Seoul, Seoul,
Korea,
2
Department
of Radiology, UT Southwestern Medical Center, Dallas,
Texas, United States
Our study is aimed at assessing neurochemical changes
caused by scopolamine (SCP) induced memory impairment
using proton in vivo MR spectroscopy. Adult male Swiss
albino mice (n=32) were used. Mice were divided into
four groups: SCP 0, 1, 3, and 5 (mg/kg). All mice
underwent 1H MR spectroscopy twice: at 30 min and 72
hours after the injection of a solution containing SCP.
Our results are in good agreement with previous
published reports that showed that SCP reduced choline
levels in the brain for about 2 hours. In vivo MR
spectroscopy is a non-invasive method with which to
evaluate the SCP induced memory impairment.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
