Abstract #2967
Anatomically matched MRS voxel reveal NAA concentration differences between cortical gray and corpus callosum white matter in the mouse brain
Juergen Baudewig 1 , Juergen Finsterbusch 2 , and Susann Boretius 1
1
Section Biomedical Imaging, Department of
Radiology and Neuroradiology,
Christian-Albrechts-University, Kiel, Germany,
2
Dept.
of Systems Neuroscience, University Medical Center
Hamburg-Eppendorf, Hamburg, Germany
In mice the cuboidal shape of voxels in classical
localized proton MR spectroscopy (MRS) in combination
the low fraction of white matter in mice hinders an
exclusive quantification of metabolites from white
matter structures. Here we used a recently developed
localization method based on 2D-selective RF excitations
to measure the corpus callosum and cortical gray matter
to compare their NAA concentrations. Reduced NAA values
in white matter compared in gray matter structures of
mice were found. 2DRF excitations in MRS to acquire
anatomically defined volumes in mice brain are a
promising tool to improve the specificity of MRS.
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