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Abstract #2968

Quantitative Assessment of Neurochemical Profiles in Rat Hippocampus after Short-Term Binge Ethanol Intoxication, Determined Using Ex vivo 1H High-Resolution NMR Spectroscopy

Do-Wan Lee 1 , Jung-Hoon Lee 1,2 , Jung-Whan Min 3 , Sang-Young Kim 1 , Jin-Young Jung 1 , Kyu-Ho Song 1 , and Bo-Young Choe 1

1 Department of Biomedical Engineering, and Research Institute of Biomedical Engineering, The Catholic University of Korea, College of Medicine, Seoul, Seoul, Korea, 2 Department of Radiology, Kyunghee Medical Center, Seoul, Korea, 3 Department of Radiological Science, The Shingu University College of Korea, Seongnam, Seongnam, Korea

The aim of present study was to provide ex vivo evidence of changes in neurochemical-profiles of rat hippocampus after 4-day binge ethanol intoxication, using 500-MHz HR-MAS 1H-NMR spectroscopy. Our results showed that Glu/tCr and Glx/tCr ratios were significantly higher in binge-ethanol group than in control group. Our main findings suggest that glutamate signals and glutamate-glutamine-cycle in hippocampal region are particularly sensitive to binge ethanol consumption. Future studies using a combination of human patients and in vivo animal investigations, as well as other neuroimaging approaches, are required to strengthen our findings and to validate translational component in binge alcohol intoxicated condition.

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