Chronic Exposure to Lead Impairs Neuronal Metabolism in Mouse Brain: A 1 H-[ 13 C]-NMR Study

Lead is a highly poisonous heavy metal with widespread use in construction and industries. Chronic exposure to lead has shown to cause systemic damage leading to permanent cognitive and behavioral impairment. Glutamatergic and GABAergic neuro-energetics were evaluated in the cerebral cortex and hippocampus of adult male C57BL6 mice using ¹ H-[ ¹³ C]-NMR spectroscopy in conjunction with infusion of [1,6- ¹³ C ₂ ]glucose. Glutamatergic neuronal activity was found to be reduced in the cortical and hippocampal regions due to chronic lead toxicity while GABAergic function was perturbed only in the hippocampus.

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