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Abstract #2970

Improved Brain Energy Metabolism in AβPP-PS1 mouse model of Alzheimers Disease upon Treatment with Ayurvedic Amalaki Rasayana: A 1 H-[ 13 C]-NMR Study

Anant Bahadur Patel 1 , Vivek Tiwari 1 , Kamal Saba 1 , and Subhash C. Lakhotia 2

1 NMR Microimaging and Spectroscopy, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, 2 Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India

AβPP-PS1 mice have been shown to closely mimic the human Alzheimer's disease (AD) pathology. The present study was undertaken to evaluate the effect of Ayurvedic drug Amalaki Rasayana (AR) on cognitive function, and cerebral metabolism associated with glutamatergic and GABAergic neurons in AβPP-PS1 mice as compared with the changes brought about by the known AD drug, donepezil. Cerebral metabolism was studied using 1 H-[ 13 C]-NMR spectroscopy together with infusion of [1,6- 13 C 2 ]glucose in 12 months old AβPP-PS1 mice. Intervention with AR significantly improved the learning/memory, and excitatory and inhibitory functions across brain regions in AβPP-PS1 mice similar to that following administration of donepezil.

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