Abstract #2970
Improved Brain Energy Metabolism in AβPP-PS1 mouse model of Alzheimers Disease upon Treatment with Ayurvedic Amalaki Rasayana: A 1 H-[ 13 C]-NMR Study
Anant Bahadur Patel 1 , Vivek Tiwari 1 , Kamal Saba 1 , and Subhash C. Lakhotia 2
1
NMR Microimaging and Spectroscopy,
CSIR-Centre for Cellular and Molecular Biology,
Hyderabad, Andhra Pradesh, India,
2
Department
of Zoology, Banaras Hindu University, Varanasi, Uttar
Pradesh, India
AβPP-PS1 mice have been shown to closely mimic the human
Alzheimer's disease (AD) pathology. The present study
was undertaken to evaluate the effect of Ayurvedic drug
Amalaki Rasayana (AR) on cognitive function, and
cerebral metabolism associated with glutamatergic and
GABAergic neurons in AβPP-PS1 mice as compared with the
changes brought about by the known AD drug, donepezil.
Cerebral metabolism was studied using
1
H-[
13
C]-NMR
spectroscopy together with infusion of [1,6-
13
C
2
]glucose
in 12 months old AβPP-PS1 mice. Intervention with AR
significantly improved the learning/memory, and
excitatory and inhibitory functions across brain regions
in AβPP-PS1 mice similar to that following
administration of donepezil.
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