1 H-[ 13 C]-NMR Study of Cerebral Energy Metabolism under sub-Acute Exposure of Aluminium Chloride in Mice: Implications for Dementia

Although aluminium has been linked to dementia type diseases including Alzheimers and Parkinsons disease in molecular aspects, the cerebral energy metabolism associated with glutamatergic and GABAergic neurons with aluminium exposure remains elusive. In this study, we have investigated the glutamatergic and GABAergic metabolism in the cerebral cortex, hippocampus and striatum regions of mice under sub-acute exposure of aluminium chloride by using ¹ H-[ ¹³ C]-NMR spectroscopy together with infusion of [1,6- ¹³ C ₂ ]glucose. Both, glutamatergic and GABAergic metabolism were found to be enhanced in aluminium chloride treated mice, which may be due to inflammatory response of aluminium toxicity in brain.

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