Meeting Banner
Abstract #2973

1 H-[ 13 C]-NMR Study of Cerebral Energy Metabolism under sub-Acute Exposure of Aluminium Chloride in Mice: Implications for Dementia

Anant Bahadur Patel 1 , Pandichelvam Veeraiah 1 , and Vivek Tiwari 1

1 NMR Microimaging and Spectroscopy, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India

Although aluminium has been linked to dementia type diseases including Alzheimers and Parkinsons disease in molecular aspects, the cerebral energy metabolism associated with glutamatergic and GABAergic neurons with aluminium exposure remains elusive. In this study, we have investigated the glutamatergic and GABAergic metabolism in the cerebral cortex, hippocampus and striatum regions of mice under sub-acute exposure of aluminium chloride by using 1 H-[ 13 C]-NMR spectroscopy together with infusion of [1,6- 13 C 2 ]glucose. Both, glutamatergic and GABAergic metabolism were found to be enhanced in aluminium chloride treated mice, which may be due to inflammatory response of aluminium toxicity in brain.

This abstract and the presentation materials are available to members only; a login is required.

Join Here