Evaluation of Efficacy of Ketamine for the Treatment of Depression like Phenotype in Mouse Model: A 1 H-[ 13 C]-NMR study

The current study investigates the response of ketamine in behavioral phenotype, and cerebral energy metabolism in the social defeat model of depression. Mice were subjected to social defeat (SD) paradigm for 10 days, and behavioral phenotypes were assessed using sucrose preference and social interaction. Ketamine was administered at sub-anesthetic dose in control and SD mice. Metabolic measurements were carried out by ¹ H-[ ¹³ C]-NMR spectroscopy in conjunction with infusion of [1,6- ¹³ C ₂ ]glucose. Intervention with ketamine improved the sucrose preference and social interaction in SD mice. Moreover, the reduced neuronal metabolic activity in SD mice could recover to control value with ketamine treatment.

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