Abstract #2975
1 H-[ 13 C]-NMR Studies of Cerebral Metabolism in Chronic Unpredictable Mild Stress Model of Depression
Anant Bahadur Patel 1 , Pravin Kumar Mishra 1 , and Madhavi Adusmilli 1
1
NMR Microimaging and Spectroscopy, CSIR-Centre
for Cellular and Molecular Biology, Hyderabad, Andhra
Pradesh, India
The molecular mechanism responsible for depression is
still elusive. The present study evaluate neural
metabolism in the prefrontal cortex of mice subjected to
chronic unpredictable mild stress (CUMS). Sucrose
preference and forced swim test were carried out to
assess the behavioral phenotype. The neuronal and
astroglial metabolism were monitored by
1
H-[
13
C]-NMR
spectroscopy together with infusion of [1,6-
13
C
2
]glucose
and [2-
13
C]acetate, respectively. Mice
subjected to CUMS exhibit increased immobility in the
forced swim test and less sucrose preference which are
typical phenotype of depression. Most importantly, the
glutamatergic, GABAergic and astroglial metabolic
activities were found to decreased in CUMS treated mice.
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